ABE Kenji, Ph.D. / Associate Professor
Pharmaceutical Business Sciences Course · Pharmaceutical Information Sciences Course
Department of Pharmaceutical and Medical Business Sciences
1. Pharmacological evaluation of 1,2,3,4-tetrahydroisoquinoline and its derivatives, endogenous parkinsonism inducing or preventing amines.
2. Investigation of developmental mechanisms and therapeutic agents in nerve injury-induced neuropathic pain models in mice.
3. Developmental mechanisms of itch sensation, especially relation to stress and itch.
Research in our group is focused on neuroscientific events in Parkinson’s disease, neuropathic pain and itch sensation using in vivo experimental animal models. Recently, research of antineoplastic drugs (such as oxaliplatin, paclitaxel and so on)-induced neuropathic pain have also begun. Some of these researches have already published.
1. Chiba T, Oka Y, Sashida H, Kanbe T, Abe K, Utsunomiya I, Taguchi K, Vincristine-induced peripheral neuropathic pain and expression of transient receptor potential vanilloid 1 in rat. J Pharmacol Sci, 133, 254-260 (2016).
2. Abe M, Munakata H, Abe K, Saito T, Horiguchi Y, Nojima H, Taguchi K, Effects of 1-cyclohexyl- and 1-cyclohexyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline on dopaminergic spontaneous discharge in nigral neurons of rats. Brain Res Bull, 121, 201-208 (2016).
3. Yamamoto K, Tsuboi M, Kanbe T, Abe K, Nakatani Y, Kawakami K, Utsunomiya I, Taguchi K, Oxaliplatin administration increases expression of the voltage-dependent calcium channel α2δ-1 subunit in the rat spinal cord. J Pharmacol Sci, 130, 117-122 (2016).