CHIBA Terumasa, Ph.D. / Assistant Professor
Division of Pharmacotherapy
Department of Pharmaceutical Sciences
1. Study on the developmental mechanisms by nerve injury-induced neuropathic pain models in mice.
Peripheral neuropathy is a common adverse effect of paclitaxel, vincristine and oxaliplatin treatment. The symptoms of anticancer drug-induced neuropathy are mostly sensory and peripheral in nature, consisting of mechanical allodynia or hyperalgesia. Research in our group is focused on analysis of transient receptor potential vanilloid 1 channel expression in the rat dorsal root ganglion and release of substance P in the rat spinal cord dorsal horn after anticancer drugs treatment.
Chiba T., Oka Y., Kambe T., Koizumi N., Abe K., Kawakami K., Utsunomiya I., Taguchi K., Paclitaxel-induced peripheral neuropathy increases substance P release in rat spinal cord, European Jounal of Pharmacology , 770, 46-51 (2016).