INOUE Hiroko, Ph.D. / Professor

Division of Pharmacotherapy

Department of Pharmaceutical Sciences

Research Topics

1. Elucidation of the pathogenesis of Epstein-Barr virus related diseases.

2. Search of the food factor involved in Epstein-Barr virus reactivation.

Epstein-Barr virus (EBV) is a ubiquitous herpes virus that infects more than 90% of the world’s population. Infection is usually asymptomatic and leads to lifelong persistence of the virus in resting recirculating memory B cells. The induction of lytic replication results in new viral infection and EBV-associated cellular transformation, and this induction may be a risk factor for malignant transformation, the development of autoimmune diseases and fatigue syndrome.The pathogenesis of these diseases is not fully understood. Based on these factors, we focus on the elucidation of the pathogenesis of EBV related diseases and search of the food factor involved in EBV reactivation.

Representative Publications

1. Yamazaki T., Ushikoshi-Nakayama R., Shirone K., Suzuki M., Abe S., Matsumoto N., Inoue H., Saito I.: Evaluation of the effect of a heat-killed lactic acid bacterium, Enterococcus faecalis 2001, on oral candidiasis. Benef. Microbes, July 10(6):661-669. (2019).

2. Makino K., Takeichi O., Imai K., Inoue H., Hatori K., Himi K., Saito I., Ochiai K., and Ogiso B., Porphyromonas endodontalis reactivates latent Epstein-Barr virus.Int Endod J,51,1410-1419 (2018).

3. Saruta J., To M., Sugimoto M., Yamamoto Y., Shimizu T., Nakagawa Y., Inoue H., Saito I., and Tsukinoki K., Salivary Gland Derived BDNF Overexpression in Mice Exerts an Anxiolytic Effect.Int J Mol Sci, 18,E1902, (2017).

4. Tsuboi H., Hagiwara S., Asashima H., Takahashi H., Hirota T., Noma H., Umehara H., Kawakami A., Nakamura H., Sano H., Tsubota K., Ogawa Y., Takamura E., Saito I., Inoue H., Nakamura S., Moriyama M., Takeuchi T., Tanaka Y., Hirata S., Mimori T., Matsumoto I., and Sumida T., Comparison of performance of the 2016 ACR-EULAR classification criteria for primary Sjogren's syndrome with other sets of criteria in Japanese patients.Ann Rheum Dis, 76,1980-1985, (2017).

5. Inoue H., Kishimoto A., Ushikoshi-Nakayama R., Hasaka A., Takahashi A., Ryo K., Muramatsu T., Ide F., Mishima K., Saito I. Resveratrol improves salivary dysfunction in a non-obese diabetic (NOD) mouse model of Sjögren’s syndrome. J. Clin. Biochem. Notr., 59, 107-112, (2016).

6. Kusakabe Y., Shindo Y., Kawai T., Takahashi Y., Koori M., Inoue H., Saito I.: Sex-Based Differences in Smgc Expression in the Submandibular Gland of C57BL/6 Mice. Pathobiology, 83, 287–294, (2016).

7. Takahashi A, Inoue H, Mishima K, Ide F, Nakayama R, Hasaka A, Ryo K, Ito Y, Sakurai T, Hasegawa Y, Saito I. Evaluation of the effects of quercetin on damaged salivary secretion. PloS one. 10, e0116008, (2015).

8. Kikuchi K, Ishige T, Ide F, Ito Y, Saito I, Hoshino M, Inoue H, Miyazaki Y, Nozaki T, Kojima M, Kusama K. Overexpression of activation-induced cytidine deaminase in MTX- and age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorders of the head and neck. J Oncol. 2015, 605750, (2015).