KATSUYAMA Soh, Ph.D. / Professor
Pharmaceutical Business Sciences Course · Pharmaceutical Information Sciences Course
Department of Pharmaceutical and Medical Business Sciences
1. Opioid mechanism of the essential oil induced peripheral antinociception.
2. The analgesic mechanism of antidepressants against pain transmission.
Our group performs the development of new pharmaceuticals, protection, and therapeutics of various diseases by exploring the interaction between a variety of drugs and certain tissue component. Our objectives are to investigate the functional association between pain-induced behavioral response and molecular alterations in the nervous system, and to discover newly improved analgesics without side effects and in an animal model of chronic pain.
1. Komatsu T, Katsuyama S, Takano F, Sakurada C, Tsuzuki M, Ogawa K, Kubota A, Morinaga O, Tabata K, Sakurada T, Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice, Neurosci Lett, 699, 103-108 (2019).
2. Komatsu T, Katsuyama S, Takano F, Okamura T, Sakurada C, Tsuzuki M, Ogawa K, Kubota A, Morinaga O, Tabata K, Sakurada T, Possible involvement of the peripheral Mu-opioid system in antinociception induced by bergamot essential oil to allodynia after peripheral nerve injury, Neurosci Lett, 686, 22-23 (2018).
3. Komatsu T, Katsuyama S, Nagase H, Mizoguchi H, Sakurada C, Tsuzuki M, Sakurada S, Sakurada T, Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal cord, Pharmacol Biochem Behav, 140, 68-74 (2016).
4. Katsuyama S, Aso H, Otowa A, Yagi T, Kishikawa Y, Komatsu T, Sakurada T, Nakamura H, Antinociceptive effects of the serotonin and noradrenaline reuptake inhibitors milnacipran and duloxetine on vincristine-induced neuropathic pain model in mice, ISRN Pain, 2014, Article ID 915464, 7 pages, (2014).
5. Katsuyama S, Mizoguchi H, Kuwahata H, Komatsu T, Nagaoka K, Nakamura H, Bagetta G, Sakurada T, Sakurada S, Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception, Eur J Pain, 17, 664-675 (2013).