KOBAYASHI Tsutomu, Ph.D. / Professor

Division of Pharmacotherapy

Department of Pharmaceutical Sciences

Research Topics

1. Computer simulation of clinical phenomena by using virtual cells.

2. Analysis of the pharmaceutical industry and current medicines.

1. Virtual cell models, working in the computer, are available for cardiac myocytes and pancreas beta cells. We can reproduce various phenomena under physiological and pathological condition, such as cardiac arrhythmia, heart failure and insuline secretion. We can also “normalize” these pathological states by optimizing activities of ion channels, transporters, etc, of the cell, which is just the simulation of drug therapy. This system is a powerful tool for discovery and development of new drugs.
2. I have a career as a senior researcher in the pharmaceutical company Tanabe Mitsubishi for 32 years. Using this experience and knowledge, we study about pharmaceutical companies from their histories to current pipelines.

Representative Publications

1. Noble D, Sarai N, Noble PJ, Kobayashi T, Matsuoka S, Noma A. Resistance of Cardiac Cells to NCX Knockout: A Model Study. Ann. N.Y. Acad. Sci. 1099, 306–309 (2007).

2. Kobayashi T, Sarai N, Matsuoka S, Noma A. ; A simulation study to rescue the Na(+)/Ca(2+) exchanger knockout mice. J Physiol Sci. 56, 211-7 (2006).

3. Kiyonaka S, Kato K, Nishida M, Mio K, Numaga T, Sawaguchi Y, Yoshida T, Wakamori M, Mori E, Numata T, Ishii M,Takemoto H, Ojida A, Watanabe K, Uemura A, Kurose H, Morii T, Kobayashi T, Sato Y, Sato C, Hamachi I, Mori Y. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc. Natl. Acad. Sci. 106, 5400-5405 (2009).