MIKUMA Toshiyasu, Ph.D. / Associate Professor

Division of Physical and Analytical Chemistry

Department of Pharmaceutical Sciences

Research Topics

1. Development of analytical methods in the field of forensic science.

2. Application of temperature-responsive chromatography for various drug analysis.

Recently, scientific analysis is an essential part of criminal investigations. To obtain effective clues, more accurate and sensitive analytical techniques have been required invariably. I have developed new analytical methods in the field of forensic science. My interest is now focused on temperature-responsive chromatography, in which a thermo-responsive polymer such as poly(N-isopropylacrylamide) is used as the stationary phase. The polymer-grafted stationary phase exhibits temperature regulated hydrophilic/hydrophobic characteristics as a result of the polymer’s conformational changes. Using the unique features, various applications have been developed for drug analysis related to criminal scenes.

Representative Publications

1. Mikuma T., Kuroki T., Yoshikawa M., Uchida R., Hiruta Y., Kanazawa H., Analysis of psychoactive drugs by temperatureresponsive chromatography, Chromatography, 38, 115-121 (2017).

2. Mikuma T., Uchida R., Kajiya M., Hiruta Y., Kanazawa H., The use of a temperature-responsive column for the direct analysis of drugs in serum by two-dimensional heart-cutting liquid chromatography, Analytical and Bioanalytical Chemistry, 409, 1059-1065 (2017).

3. Mikuma T., Iwata Y.T., Miyaguchi H., Kuwayama K., Tsujikawa K., Kanamori T., Kanazawa H., Inoue H., Approaching over 10 000-fold sensitivity increase in chiral capillary electrophoresis: cation-selective exhaustive injection and sweeping cyclodextrin-modified micellar electrokinetic chromatography, Electrophoresis, 37, 2970-2976 (2016).

4. Mikuma T., Iwata Y.T., Miyaguchi H., Kuwayama K., Tsujikawa K., Kanamori T., Inoue H., The use of a sulfonated capillary on chiral capillary electrophoresis/mass spectrometry of amphetamine-type stimulants for methamphetamine impurity profiling, Forensic Science International, 249, 59-65 (2015).