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TAKAJO Tokuko, Ph.D. / Senior Assistant Professor

Pharmaceutical Business Sciences Course · Pharmaceutical Information Sciences Course

Department of Pharmaceutical and Medical Business Sciences

Research Topics

1. Measurement of antioxidant activity.

2. Detection of reactive oxygen species by irradiation of cold atmospheric plasma.

3. Evaluation of lipid peroxidation and preventation substance.

Our main research field is "reactive oxygen species and antioxidant", and the current main theme is specific detection of singlet oxygen, which is one of reactive oxygen species. In addition we are also studying about reactive oxygen species generated by irradiation of cold atmospheric plasma to water. To detect reactive oxygen species and free radicals, we use electron spin resonance (ESR) spectroscopy in combination with spin-trap or spinprobe techniques.

Representative Publications

1. Takajo T, Kurihara Y, Iwase K, Miyake D, Tsuchida K, Anzai K., Basic investigations of singlet oxygen detection systems with ESR for the measurement of singlet oxygen quenching activities, Chem Pharm Bull (Tokyo), 68, 150–154 (2020).

2. Anzai K., Aoki T., Koshimizu S., Takaya R., Tsuchida K., Takajo T., Formation of reactive oxygen species by irradiation of cold atmospheric pressure plasma jet to water depends on the irrasiation distance, J Clin Biochem Nutr, 64, 187–193 (2019).

3. Koshiishi I., Yokota A., Takajo T., Nitric oxide converts fatty acid alkoxyl radicals into fatty acid allyl radicals, Arch Biochem Biophys, 516, 154–159 (2011).

4. Takajo T., Tsuchida K., Yokota A., Koshiishi I., Trapping of fatty acid allyl radicals generated in lipoxygenase reactions in biological fluids by nitroxyl radicals, Bimed Chromatogr, 24, 794–797 (2010).

5. Takajo T., Tsuchida K., Ueno K., Koshiishi I., Feedback activation of ferrous 5-lipoxygenase during leukotriene synthesis by coexisting linoleic acid, J Lipid Res, 48, 1371–1377 (2007).