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  4. TSUCHIDA Kazunori, Ph.D. / Associate Professor

TSUCHIDA Kazunori, Ph.D. / Associate Professor

Division of Physical and Analytical Chemistry

Department of Pharmaceutical Sciences

Research Topics

1. Analysis of the antioxidant capacities using ORAC/SOAC assay.

2. Evaluate the lipid radicals generated in lipoxygenases.

3. Biosynthesis of Chondrotin Sulfates/Heparan Sulfates.

Research in my interest is; 1. To analyse the antioxidant capacities using ORAC (Oxygen Radical Absorbance Capacity) assay and SOAC assay (a Singlet Oxygen Absorption Capacity). 2. To evaluate the physiological functions of the lipid radicals produced in a lipoxygenases at lower oxygen content. 3. To study the bioshynthesis of Chondroitin Sulfate/Dermatan Sulfate and Heparan Sulfate/Heparin.

Representative Publications

1. Takajo T, Tsuchida K, Yokota A, Koshiishi I. Trapping of fatty acid allyl radicals generated in lipoxygenase reactions in biological fluids by nitroxyl radical. Biomed. Chromatogr. 24, 794-797 (2010).

2. Takajo T, Tsuchida K, Ueno K, Koshiishi I. Feedback activation of ferrous 5-lipoxygenase during leukotriene synthesis by coexisting linoleic acid. J. Lipid Res., 48, 1371-1377 (2007).

3. Pedersen LC, Tsuchida K, Kitagawa H, Sugahara K, Darden TA, Negishi M. Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I. J. Biol. Chem., 275, 34580-34585(2000).

4. Tsuchida K, Lind T, Kitagawa H, Lindahl U, Sugahara K, Lidholt K. Purification and characterization of fetal bovine serum beta-N-acetyl-D-galactosaminyltransferase and beta-